Drotaverine is a phosphodiesterase-4 inhibitor used to alleviate gastrointestinal and genitourinary smooth muscle spasms. Drotaverine is an antispasmodic drug that works by inhibiting phosphodiesterase-4 (PDE4).
- Mechanism
- Curator reviewed · 1 reference
Drotaverine is an inhibitor of phosphodiesterase 4 (PDE4), which is an enzyme responsible for the degradation of cyclic adenosine monophosphate (cAMP). Inhibition of PDE4 leads to elevated levels of cAMP, leading to smooth muscle relaxation. Recent research showed that low levels of cAMP have been associated with brain tumorigenesis, leading to the investigation of PDE4 inhibitors as potential anticancer agents.
- Primary indication
- Drotaverine is used to alleviate gastrointestinal and genitourinary smooth muscle spasms, such as cholecystitis and gallbladder disorders.Curator reviewed · 11 structured indications
- Formula / weight
- C24H31NO4 · 397.5072 g/mol (avg)
- Also known as
- Drotaverin
Resolves to
OMFNSKIUKYOYRG-MOSHPQCFSA-NSMILESCCOC1=C(OCC)C=C(\C=C2/NCCC3=CC(OCC)=C(OCC)C=C23)C=C1What you can answer from here — as of September 21, 2026
Which drugs share a target with Drotaverine, and which of those have an active Phase 3 trial?
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